RadAjaxManager can AJAX-enable specific controls dynamically. Here, the ImageButtons are ajaxified intercepting the ItemCreated event hander of the grid.
Here is a code snippet showing how this is achieved:
When a user clicks an Image button, the corresponding item is added to the shopping cart (RadGrid2).
Both grids are AJAX-enabled with declaratively applied settings in the mark-up code. For further information, please refer to the Default.aspx section.