The RadToolTip fully supports right-to-left (RTL) language locales. The tooltips are created and added to the page as children of the body element and in order to turn on the RTL support you should set dir=rtl to the html or body elements.
Use the Tab key to move from one TextBox to the other and see how a RadToolTip which
supports RTL opens on focus of the target control. Position the mouse over the Help
button to recieve additional instructions.